ParkinsonCanadaV1, Main, Exploration, bibRecord, 000013

The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.

Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014

The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.

Auteurs : Naomi P. Visanji [Canada] ; Brit Mollenhauer [Allemagne] ; Thomas G. Beach [États-Unis] ; Charles H. Adler [États-Unis] ; Christopher S. Coffey [États-Unis] ; Catherine M. Kopil [États-Unis] ; Kuldip D. Dave [États-Unis] ; Tatiana Foroud [États-Unis] ; Lana Chahine [États-Unis] ; Danna Jennings [États-Unis]

Source :

Biomarkers in medicine [ 1752-0371 ] ; 2017.

RBID : pubmed:28353371

Abstract

The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.

DOI: 10.2217/bmm-2016-0366
PubMed: 28353371

Affiliations:

Le document en format XML

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<author><name sortKey="Chahine, Lana" sort="Chahine, Lana" uniqKey="Chahine L" first="Lana" last="Chahine">Lana Chahine</name>
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<front><div type="abstract" xml:lang="en">The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.</div>
</front>
</TEI>
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<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name>
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<name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name>
<name sortKey="Chahine, Lana" sort="Chahine, Lana" uniqKey="Chahine L" first="Lana" last="Chahine">Lana Chahine</name>
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<name sortKey="Jennings, Danna" sort="Jennings, Danna" uniqKey="Jennings D" first="Danna" last="Jennings">Danna Jennings</name>
<name sortKey="Kopil, Catherine M" sort="Kopil, Catherine M" uniqKey="Kopil C" first="Catherine M" last="Kopil">Catherine M. Kopil</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.

The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.

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	La maladie de Parkinson au Canada (serveur d'exploration)
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